JoVE Journal

Neuroscience

You have full access to this content through

Nanyang Technological University

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Studies have shown that cathodal transcranial direct-current stimulation can produce suppressive effects on drug-resistant seizures. In this study, an in vitro experimental setup was devised in which the direct-current stimulation and multielectrode array recording of seizure-like activity were evaluated in mice brain slice preparation. The direct-current stimulation parameters were evaluated.

Chapters in this video

0:05

Title

0:59

Preparation of Medial Thalamus-anterior Cingulate Cortex Brain Slice

3:01

Preparation of Perfusion Chamber for Multielectrode Array Recording and Electric Field Generation

4:23

Electrically-induced Cortical Synaptic Responses and Seizure-like Activity

5:58

Testing Effect of DCS on Evoked Cortical Responses

7:37

Results: Testing of Evoked Responses and Effect of DCS on Seizure Activity

8:37

Conclusion

Related Videos

We use cookies to enhance your experience on our website.

By continuing to use our website or clicking “Continue”, you are agreeing to accept our cookies.

Learn More