JoVE Journal

Neuroscience

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Nanyang Technological University

마우스 뇌 조각 준비에서 발작 같은 활동의 직류 자극 및 다중 전극 배열 기록

Studies have shown that cathodal transcranial direct-current stimulation can produce suppressive effects on drug-resistant seizures. In this study, an in vitro experimental setup was devised in which the direct-current stimulation and multielectrode array recording of seizure-like activity were evaluated in mice brain slice preparation. The direct-current stimulation parameters were evaluated.

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Title

0:59

Preparation of Medial Thalamus-anterior Cingulate Cortex Brain Slice

3:01

Preparation of Perfusion Chamber for Multielectrode Array Recording and Electric Field Generation

4:23

Electrically-induced Cortical Synaptic Responses and Seizure-like Activity

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Testing Effect of DCS on Evoked Cortical Responses

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Results: Testing of Evoked Responses and Effect of DCS on Seizure Activity

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Conclusion

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