JoVE Journal

Neuroscience

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Nanyang Technological University

A estimulação de corrente contínua e Multi-eletrodo de gravação matriz de perda de consciência em Ratos Cérebro Slice Preparação

Studies have shown that cathodal transcranial direct-current stimulation can produce suppressive effects on drug-resistant seizures. In this study, an in vitro experimental setup was devised in which the direct-current stimulation and multielectrode array recording of seizure-like activity were evaluated in mice brain slice preparation. The direct-current stimulation parameters were evaluated.

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Title

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Preparation of Medial Thalamus-anterior Cingulate Cortex Brain Slice

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Preparation of Perfusion Chamber for Multielectrode Array Recording and Electric Field Generation

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Electrically-induced Cortical Synaptic Responses and Seizure-like Activity

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Testing Effect of DCS on Evoked Cortical Responses

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Results: Testing of Evoked Responses and Effect of DCS on Seizure Activity

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Conclusion

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