Chapter 15
Mass Spectrometry Fragmentation Methods
质谱法:长链烷烃碎裂
The molecular ions of linear alkanes prefer to fragment at the carbon-carbon bond away from the end of the chain since the cleavage of an inner bond ...
质谱分析:支链烷烃碎裂
This lesson delves into the mass spectrometry of branched alkane fragmentation. Branched alkanes possess secondary or tertiary carbon atoms, which ...
质谱法:环烷烃碎裂
In mass spectrometry, cycloalkanes exhibit distinct fragmentation patterns due to the inherent stability of their molecular ions compared to linear or ...
质谱分析:烯烃碎裂
Alkenes lose one electron from the unsaturated π bond upon ionization and form stable molecular ions. Further fragmentation of alkenes occurs through ...
质谱法:环烯烃碎裂
The molecular ions of cycloalkenes undergo fragmentation via a retro-Diels–Alder reaction.
The reaction proceeds via the cleavage of two ...
质谱法:炔烃碎裂
The fragmentation of alkynes preferentially occurs at the carbon–carbon bond between the α and β carbon of the alkyne bond to generate a ...
质谱法:醇碎裂
Alcohols (R-OH) ionize to lose one non-bonded electron from the oxygen atom, forming molecular ions. Due to their tendency to fragment rapidly, the ...
质谱法:芳香族化合物碎裂
Upon ionization, aromatic compounds generate a molecular ion that is observed as a prominent peak in their mass spectra. For example, the molecular ion ...
质谱法:胺碎裂
Amines can be identified using mass spectroscopy based on their characteristic fragmentation patterns. The molecular ions of amines undergo fragmentation ...
Mass Spectrometry: Alkyl Halide Fragmentation
Chlorine isotopes exist as 35Cl and 37Cl in a 3:1 ratio, while bromine isotopes exist as 79Br and 81Br in a 1:1 ratio. The mass spectrum of alkyl halides ...
Mass Spectrometry: Alkyl Halide Fragmentation
Chlorine isotopes exist as 35Cl and 37Cl in a 3:1 ratio, while bromine isotopes exist as 79Br and 81Br in a 1:1 ratio. The mass spectrum of alkyl halides ...
质谱法:醛和酮碎裂
In mass spectrometry, the fragmentation of aliphatic aldehydes and ketones generally occurs through three key mechanisms: α-cleavage, inductive ...
质谱分析:羧酸、酯和酰胺碎裂
The fragmentation patterns observed for compounds such as carboxylic acids, esters, and amides in the mass spectra include ⍺-cleavage and McLafferty ...
化学电离 （CI） 质谱
The molecular ion peak of a molecule in the mass spectrum provides vital information for molecular identification. However, conventional electron impact ...
电喷雾电离 （ESI） 质谱
Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional ...
基质辅助激光解吸电离 （MALDI）
Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and ...
版权所属 © 2025 MyJoVE 公司版权所有，本公司不涉及任何医疗业务和医疗服务。