Chapter 4
Pharmacokinetics: Drug Distribution and Protein Binding
Distribuição de medicamentos: visão geral
Distribution refers to the two-way movement of a drug between different compartments within the body.
It is a passive process driven by the concentration ...
Fatores que afetam a distribuição de medicamentos: permeabilidade tecidual
Drug distribution across biological membranes to target tissues relies on the drug's physicochemical properties, such as molecular size, ionization ...
Fatores que afetam a distribuição de medicamentos: barreiras fisiológicas
Drug distribution is governed by several physiological barriers.
The simple capillary endothelial barrier limits the passage of drugs larger than 600 ...
Fatores que afetam a distribuição de medicamentos: taxa de perfusão de órgãos
Drug distribution can be perfusion rate-limited, particularly when the drug is highly lipophilic, and the membrane to cross is highly permeable.
The ...
Fatores que afetam a distribuição de medicamentos: fatores diversos
Drug distribution can be affected by various factors.
It can vary with age due to differences in body composition. For instance, older adults have less ...
Volume de Distribuição
The apparent volume of distribution or Vd is a key pharmacokinetic parameter signifying the hypothetical body fluid volume into which a drug disperses.
It ...
Ligação proteína-droga: mecanismo e cinética
Protein-drug binding is the interaction between drugs and proteins in the body.
It can be either intracellular binding, which involves drug interactions ...
Ligação de medicamentos a componentes sanguíneos
When drugs enter the systemic circulation, they interact with blood components like human serum albumin or HSA, α1-acid glycoprotein or AAG, ...
Ligação tecido-fármaco: localização de fármacos e seu significado
Body tissues comprise 40-90% of body weight depending on body composition. They can serve as drug storage sites, competing with plasma binding sites.
...
Ligação proteína-droga: métodos de determinação
Protein-drug binding is determined through indirect and direct methods.
Indirect methods involve isolating the bound drug from its free form in biological ...
Fatores que afetam a ligação proteína-droga: Fatores relacionados a drogas
Protein-drug binding can be affected by various drug-related factors.
The degree of protein binding is closely related to a drug's lipophilicity, with ...
Fatores que afetam a ligação proteína-droga: fatores relacionados à proteína
Drug binding to proteins depends on various factors, including physicochemical properties, protein concentration, disease states, and the number of ...
Fatores que afetam a ligação proteína-droga: interações medicamentosas
Drug displacement interactions arise when drugs compete for the same binding site, leading to displacement.
The extent of displacement depends on the ...
Fatores que afetam a ligação proteína-droga: fatores relacionados ao paciente
Protein-drug binding varies with many patient-related factors.
Age impacts binding due to varying protein content in different age groups. Neonates ...
Copyright © 2025 MyJoVE Corporation. Todos os direitos reservados