Chapter 4
Pharmacokinetics: Drug Distribution and Protein Binding
Dystrybucja leków: Przegląd
Distribution refers to the two-way movement of a drug between different compartments within the body.
It is a passive process driven by the concentration ...
Czynniki wpływające na dystrybucję leków: przepuszczalność tkanek
Drug distribution across biological membranes to target tissues relies on the drug's physicochemical properties, such as molecular size, ionization ...
Czynniki wpływające na dystrybucję leków: bariery fizjologiczne
Drug distribution is governed by several physiological barriers.
The simple capillary endothelial barrier limits the passage of drugs larger than 600 ...
Czynniki wpływające na dystrybucję leków: szybkość perfuzji narządowej
Drug distribution can be perfusion rate-limited, particularly when the drug is highly lipophilic, and the membrane to cross is highly permeable.
The ...
Czynniki wpływające na dystrybucję leków: Różne czynniki
Drug distribution can be affected by various factors.
It can vary with age due to differences in body composition. For instance, older adults have less ...
Wolumen dystrybucji
The apparent volume of distribution or Vd is a key pharmacokinetic parameter signifying the hypothetical body fluid volume into which a drug disperses.
It ...
Wiązanie białko-lek: mechanizm i kinetyka
Protein-drug binding is the interaction between drugs and proteins in the body.
It can be either intracellular binding, which involves drug interactions ...
Wiązanie leku ze składnikami krwi
When drugs enter the systemic circulation, they interact with blood components like human serum albumin or HSA, α1-acid glycoprotein or AAG, ...
Wiązanie tkanka-lek: lokalizacja leków i jej znaczenie
Body tissues comprise 40-90% of body weight depending on body composition. They can serve as drug storage sites, competing with plasma binding sites.
...
Wiązanie białka z lekiem: metody oznaczania
Protein-drug binding is determined through indirect and direct methods.
Indirect methods involve isolating the bound drug from its free form in biological ...
Czynniki wpływające na wiązanie białka z lekami: Czynniki związane z lekiem
Protein-drug binding can be affected by various drug-related factors.
The degree of protein binding is closely related to a drug's lipophilicity, with ...
Czynniki wpływające na wiązanie białka z lekami: Czynniki związane z białkiem
Drug binding to proteins depends on various factors, including physicochemical properties, protein concentration, disease states, and the number of ...
Czynniki wpływające na wiązanie białka z lekami: interakcje z innymi lekami
Drug displacement interactions arise when drugs compete for the same binding site, leading to displacement.
The extent of displacement depends on the ...
Czynniki wpływające na wiązanie białka z lekami: czynniki związane z pacjentem
Protein-drug binding varies with many patient-related factors.
Age impacts binding due to varying protein content in different age groups. Neonates ...
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