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Medicine

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Nanyang Technological University

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

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3.3K Views

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05:41 min

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December 16th, 2022

DOI :

10.3791/63921-v

December 16th, 2022

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Hui-Chun Ku¹, Ding-Kuo Chien²^,³^,⁴^,⁵, Chuan-Lei Chao⁵^,⁶, Shih-Yi Lee⁵^,⁷

¹Department of Life Science, Fu Jen Catholic University, ²Department of Medicine, MacKay Medical College, ³Department of Emergency Medicine, MacKay Memorial Hospital, ⁴Graduate Institute of Injury Prevention and Control, Taipei Medical University, ⁵MacKay Junior College of Medicine, Nursing, and Management, ⁶Division of Cardiology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, ⁷Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, MacKay Memorial Hospital

Podsumowanie

Herein, we present a protocol focusing on the quality control of the left anterior descending coronary artery ligation by technically modifying the traditional procedure in rats for acute myocardial ischemia-reperfusion research.

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Left Anterior Descending Coronary Artery

Ischemia reperfusion Injury

Cardiac Procedure

Surgical Technique

Ligation Protocol

Saline Preparation

Sterile Equipment

Anesthetization

Endotracheal Tube

Intercostal Space

Surgical Window Creation

Tissue Management

Rozdziały w tym wideo

0:05

Introduction

0:30

Preparation Before Surgery

1:37

Left Anterior Descending Coronary Artery (LAD Ligation)

4:33

Results: Validation of LAD Ligation and Quantification of Infarct Size and Area at Risk

5:18

Conclusion

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