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Nanyang Technological University

初期の飢餓応答でCoronin Aの機能を調査

The social amoeba Dictyostelium discoideum undergoes a developmental transition into a multicellular organism when starved. The evolutionary conserved protein coronin A plays a crucial role in the initiation of development. Using aggregation assays as our main method, we aim to elucidate the role of coronin A in early development.

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Title

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Observe the Early Starvation Response of Dictyostelium discoideum by Time-lapse Microscopy

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cAMP Pulsing of Dictyostelium discoideum Cells During Starvation

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Induction of Dictyostelium discoideum Development Through Exposure to Conditioned Medium

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Results: cAMP Pulses Rescue the Early Developmental Defect of corA- Dictyostelium discoideum

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Conclusion

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