A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research

1.1K Views

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10:25 min

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April 12th, 2024

DOI :

10.3791/66383-v

April 12th, 2024

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W. Jeffrey Zabel*¹, Nader Allam*¹, Hector Alejandro Contreras Sanchez¹, Warren Foltz²^,³, Costel Flueraru⁴, Edward Taylor²^,³, Alex Vitkin¹^,²^,³

¹Department of Medical Biophysics, University of Toronto, ²Radiation Medicine Program, Princess Margaret Cancer Centre, ³Department of Radiation Oncology, University of Toronto, ⁴Advanced Electronic and Photonics Research Center, National Research Council of Canada

Summary

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Dorsal Skinfold Window Chamber

Tumor Mouse Model

Intravital Microscopy

Magnetic Resonance Imaging

Translational Cancer Research

Preclinical Imaging

MRI Correlation

Perfusion sensitive Imaging

Biophotonics

Optical Coherence Tomography

Radiotherapy Biomarkers

3D Printing

Longitudinal Studies

Co registration

Stereotactic Body Radiation Therapy

Tumor Microvasculature

Chapters in this video

0:00

Introduction

2:50

Tumor Cells Inoculation in Mice Through Precise Landmarking and Injection Techniques

4:57

Window Chamber Surgery in Tumor Cell Injected Mice for Tumor Growth Visualization and Imaging

6:59

Integrative Imaging Techniques for Tumor Analysis in Mice

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