Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery

1.3K Views

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07:25 min

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August 18th, 2023

DOI :

10.3791/65785-v

August 18th, 2023

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Cheng-Yang Zhang*¹^,², Xiao-Feng Zhang*³, Jun Yuan*¹^,², Yuan-Feng Gong⁴, Hui Tang⁴, Wan-Yu Guo¹^,², Tong-Yan Li¹^,², Cai-Wen Li¹^,², Yun-Qiang Tang⁴, Ning-Fang Ma¹^,², Ming Liu¹^,²

¹Affiliated Cancer Hospital and Institute of Guangzhou Medical University, ²Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Center for Cancer Research and Translational Medicine, School of Basic Medical Sciences, Guangzhou Medical University, ³Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, ⁴Department of Hepatobiliary Surgery, Affiliated Cancer Hospital, Guangzhou Medical University

Summary

Explore More Videos

Hepatocellular Carcinoma

Organoid Model

Drug Discovery

Molecular Pathogenesis

Therapeutic Targets

Cancer Metastasis

Organoid Culture

Patient derived Organoids

Chapters in this video

0:00

Introduction

1:26

Hepatocellular Carcinoma Tissue Dissociation for Organoid Culture

3:27

Hepatocellular Carcinoma Organoid Culture and Digestion to Study Liver Cancer Pathogenesis

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