A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

989 Views

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08:42 min

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November 21st, 2023

DOI :

10.3791/64450-v

November 21st, 2023

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Julian Dilley*¹^,²^,³, Hessam Noori-Dokht*³^,⁴^,⁶, Abhijit Seetharam¹, Margaret Bello¹^,³, Aaron Nanavaty¹^,³, Roman M. Natoli²^,³, Todd McKinley¹^,²^,³, Zachary Bault⁵, Diane Wagner²^,³^,⁶, Uma Sankar¹^,³

¹Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, ²Department of Orthopaedic Surgery, Indiana University School of Medicine, ³Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, ⁴School of Mechanical Engineering, Purdue University, ⁵Large Animal Resource Center, Indiana University School of Medicine, ⁶Department of Mechanical and Energy Engineering, Indiana University-Purdue University Indianapolis

Summary

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Cartilage Impact Model

Post traumatic Osteoarthritis

Femoral Shaft Fracture

Surgical Procedure

Anesthetized Rabbit

Arthrotomy

Medial Femoral Condyle

Self retaining Weitlaner Retractor

Surgical Site Preparation

Chapters in this video

0:04

Introduction

0:47

Animal Preparation

1:49

Surgical Exposure

3:36

Impact of the Femoral Condyle

5:25

Surgical Site Closure

6:23

Results: Assessing Osteoarthritis Severity and Apoptotic Chondrocytes in the Impacted Medial Femoral Condyle

7:58

Conclusion

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