Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

2.0K Views

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09:31 min

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February 14th, 2022

DOI :

10.3791/62982-v

February 14th, 2022

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Keir A. Forgie¹^,², Nicholas Fialka³, Max Buchko¹^,², Sayed Himmat⁴, Sanaz Hatami⁴, Xiao Qi⁴, Xiuhua Wang⁴, Katie-Marie Buswell⁵, Ryan Edgar⁵, Darren H. Freed¹^,²^,⁶^,⁷, Jayan Nagendran¹^,²^,⁶^,⁷

¹Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine, University of Alberta, ²Mazankowski Alberta Heart Institute, ³Faculty of Medicine and Dentistry, University of Alberta, ⁴Department of Surgery, Faculty of Medicine, University of Alberta, ⁵Ray Rajotte Surgical-Medical Research Institute (SMRI), University of Alberta, ⁶Alberta Transplant Institute, ⁷Canadian Donation and Transplantation Research Program

Summary

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Normothermic Negative Pressure Ventilation

Ex Situ Lung Perfusion

ESLP Device

Donor Lungs Preservation

Lung Injury Reduction

Negative Pressure Ventilation

Physiological Mechanism

Surgical Techniques

Juvenile Pig Lungs

Expiratory Tidal Volume

Cardiectomy

Mediastinal Pleura Removal

Deaver Retractor

Inferior Pulmonary Ligament

Trachea Clamping

Surgical Dissection

Chapters in this video

0:05

Introduction

0:57

Pneumonectomy

2:58

Placement of the Lungs onto the Ex‐Situ Lung Perfusion (ESLP) Apparatus

4:35

Initiation of Perfusion and Ventilation

7:44

Results: Analysis of Blood Gas and Functional Parameters During Evaluation Modes Over 12 Hours of ESLP and NPV‐ESLP

8:57

Conclusion

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