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Nanyang Technological University

Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats

10.5K Views

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05:54 min

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April 4th, 2019

DOI :

10.3791/59327-v

April 4th, 2019

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Marie Mortreux¹, Daniela Riveros¹, Mary L. Bouxsein², Seward B. Rutkove¹

¹Department of Neurology, Harvard Medical School - Beth Israel Deaconess Medical Center, ²Department of Orthopaedics, Harvard Medical School - Beth Israel Deaconess Medical Center

Summary

By using an innovative ground-based analogue model, we are able to simulate a space mission including a trip to (0 g) and a stay on Mars (0.38 g) in rats. This model allows for a longitudinal assessment of the physiological changes occurring during the two hypo-gravitational stages of the mission.

Explore More Videos

Hindlimb Unloading

Partial Weight Bearing

Mars Mission Model

Physiological Challenges

Astronaut Health

Behavior Changes

Memory Performance

Stress Responses

Research Protocol

Stainless Steel Chain

Body Weight Recording

Chapters in this video

0:04

Title

1:01

Hindlimb Unloading

2:06

Partial Weight Bearing

3:09

Assessment of Hindlimb Grip Force

3:46

Results: Mimic a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats

4:59

Conclusion

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