Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

9.7K Views

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08:54 min

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April 18th, 2018

DOI :

10.3791/56817-v

April 18th, 2018

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Vijay Rajagopal¹^,²^,³, Gregory Bass²^,³, Shouryadipta Ghosh¹^,²^,³, Hilary Hunt²^,⁴, Cameron Walker⁵, Eric Hanssen⁶, Edmund Crampin²^,³^,⁴^,⁷^,⁸, Christian Soeller⁹

¹Cell Structure and Mechanobiology Group, University of Melbourne, ²Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, ³Department of Biomedical Engineering, University of Melbourne, ⁴School of Mathematics and Statistics, Faculty of Science, University of Melbourne, ⁵Department of Engineering Science, University of Auckland, ⁶Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, ⁷ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, ⁸School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, ⁹Living Systems Institute, University of Exeter

Summary

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Keywords Finite Element Model

Cardiomyocyte

Cellular Architecture

Cardiac Cell Systems Biology

Chapters in this video

0:04

Title

1:19

Segment Myofibrils and Mitochondria Regions from the EM 3D Image Dataset

3:05

Create a Finite Element Mesh from the Segmented Components

4:36

Mathematically Map the Spatially Varying Density of Ion-channels of Interest onto the Finite Element Mesh

6:51

Results: A Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte

8:13

Conclusion

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