建立一种结构逼真的心肌细胞的有限元几何模型研究蜂窝结构在心肌系统生物学中的作用

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9.7K Views

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08:54 min

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April 18th, 2018

DOI :

10.3791/56817-v

April 18th, 2018

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Vijay Rajagopal¹^,²^,³, Gregory Bass²^,³, Shouryadipta Ghosh¹^,²^,³, Hilary Hunt²^,⁴, Cameron Walker⁵, Eric Hanssen⁶, Edmund Crampin²^,³^,⁴^,⁷^,⁸, Christian Soeller⁹

¹Cell Structure and Mechanobiology Group, University of Melbourne, ²Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, ³Department of Biomedical Engineering, University of Melbourne, ⁴School of Mathematics and Statistics, Faculty of Science, University of Melbourne, ⁵Department of Engineering Science, University of Auckland, ⁶Advanced Microscopy Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, ⁷ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, ⁸School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, ⁹Living Systems Institute, University of Exeter

摘要

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134

此视频中的章节

0:04

Title

1:19

Segment Myofibrils and Mitochondria Regions from the EM 3D Image Dataset

3:05

Create a Finite Element Mesh from the Segmented Components

4:36

Mathematically Map the Spatially Varying Density of Ion-channels of Interest onto the Finite Element Mesh

6:51

Results: A Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte

8:13

Conclusion

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