A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

11.4K Views

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07:38 min

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April 13th, 2018

DOI :

10.3791/56443-v

April 13th, 2018

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Francesca Ruscitti¹, Francesca Ravanetti², Gaetano Donofrio², Yanto Ridwan³, Paula van Heijningen³, Jeroen Essers⁴, Gino Villetti¹, Antonio Cacchioli², Wim Vos⁵, Franco Fabio Stellari¹

¹Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., ²Department of Veterinary Science, University of Parma, ³Department of Molecular Genetics, Erasmus MC, ⁴Department of Molecular Genetics, Vascular Surgery, Radiation Oncology, Erasmus MC, ⁵Fluidda NV

Summary

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Keywords Micro CT

Fluorescence Molecular Tomography

Lung Fibrosis

IPF

Mouse Model

Longitudinal Assessment

Chapters in this video

0:04

Title

0:56

Intratracheal Administration of Bleomycin

1:46

Probe Injection for Fluorescence Molecular Tomography

2:25

Fluorescence Molecular Tomography Imaging

3:45

In Vivo Imaging by Micro-CT

5:45

Results: Time-course and Quantification of Bleomycin-induced Lung Fibrosis

7:09

Conclusion

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