JoVE Journal

Behavior

This content is Open Access.

The Knob Supination Task: A Semi-automated Method for Assessing Forelimb Function in Rats

9.2K Views

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09:26 min

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September 28th, 2017

DOI :

10.3791/56341-v

September 28th, 2017

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Samuel D. Butensky¹, Thelma Bethea¹, Joshua Santos¹, Anil Sindhurakar¹, Eric Meyers²^,³, Andrew M. Sloan²^,³, Robert L. Rennaker II²^,³, Jason B. Carmel¹^,⁴^,⁵

¹Burke Medical Research Institute, ²Texas Biomedical Center, The University of Texas at Dallas, ³Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, ⁴Brain and Mind Research Institute, Weill Cornell Medical College, ⁵Departments of Neurology and Pediatrics, Weill Cornell Medical College

Summary

This manuscript describes a semi-automated task that quantifies supination in rats. Rats reach, grasp, and supinate a spherical manipulandum. The rat is rewarded with a pellet if the turn angle exceeds a criterion set by the user. This task increases throughput, sensitivity to injury, and objectivity compared to traditional tasks.

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