Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
7.6K Views
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06:51 min
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August 10th, 2018
DOI :
August 10th, 2018
•Naemeh Pourshafie1, Philip R. Lee2, Ke-lian Chen1, George G. Harmison1, Laura C. Bott1,3, Kenneth H. Fischbeck1, Carlo Rinaldi1,4
1Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 2Section on Nervous System Development and Plasticity, The Eunice Kennedy Shriver National Institute of Child and Human Development, National Institutes of Health, 3Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, 4Department of Physiology, Anatomy and Genetics, University of Oxford
Chapters in this video
0:04
Title
0:48
Tail Vein Injection of AAV-miRNA Plasmid
2:14
Behavioral Assays: Hanging Wire and Foot Print Assay
3:30
Tissue Harvest
4:27
Results: Treatment of SBMA Mice with miRNA
5:59
Conclusion
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