Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
14.6K Views
•
08:29 min
•
October 2nd, 2014
DOI :
October 2nd, 2014
•Adriana D. Corben*1, Mohammad M. Uddin*2, Brooke Crawford3, Mohammad Farooq4, Shanu Modi5, John Gerecitano5, Gabriela Chiosis2, Mary L. Alpaugh6
1Department of Pathology, Memorial Sloan Kettering Cancer Center, 2Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 3Department of Radiology, Weill Cornell Medical College, 4Department of Medicine, Memorial Sloan Kettering Cancer Center, 5Department of Oncology, Memorial Sloan Kettering Cancer Center, 6Department of Surgery, Memorial Sloan Kettering Cancer Center
Chapters in this video
0:05
Title
2:30
Tissue Procurement
4:09
Preparation of Materials for Sectioning and Vibratome Settings
5:19
Tissue Sectioning, Treatment, and Analyses
6:25
Results: Ex Vivo Metastatic Breast Cancer Response to Heat Shock Protein 90 Inhibitor
7:56
Conclusion
Related Videos
08:26
Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
24.8K Views
06:16
Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
12.5K Views
10:27
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
7.2K Views
10:32
Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
10.7K Views
08:27
Measuring Real-time Drug Response in Organotypic Tumor Tissue Slices
11.3K Views
07:45
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
5.9K Views
07:42
Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
4.8K Views
08:52
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
3.9K Views
08:36
In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells
1.6K Views
09:19
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
8.2K Views
Copyright © 2025 MyJoVE Corporation. All rights reserved