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Nanyang Technological University

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

9.2K Views

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11:57 min

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February 23rd, 2015

DOI :

10.3791/52105-v

February 23rd, 2015

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Klaus Zweckberger¹, Yang Liu¹, Jian Wang¹, Nicole Forgione¹, Michael G. Fehlings¹^,²^,³

¹Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, University Health Network, Krembil Neuroscience Centre, ²Department of Surgery, University of Toronto, ³Institute of Medical Sciences, University of Toronto

Summary

Treating cervical spinal cord injury with both self-assembling peptides (SAP) and neural precursor cells (NPC), together with growth factors, is a promising approach to promote regeneration and recovery. A contusion/compression aneurysm clip rat model of cervical SCI and combined treatment involving SAP injection and NPC transplantation is established.

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Keywords Spinal Cord Injury

Secondary Mechanisms

Tissue Scarring

Intramedullary Cavities

Self assembling Peptides

Neural Precursor Cells

Chapters in this video

0:05

Title

1:20

Induction of Cervical Clip Contusion

5:36

Injection of Self-assembling Peptides (SAPs)

7:03

Injection of Neural Precursor Cells (NPCs)

8:34

Implantation of Subdural Pumps for Growth Factor Application

10:39

Results: Successful Delivery of SAPs and NPCs and Scaffold Formation

11:27

Conclusion

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