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Core - Pharmacology

    Chapter 8

    Local Anesthetics

    8.1 : Local Anesthetics: Chemistry and Structure-Activity Relationship01:27

    8.1 : Local Anesthetics: Chemistry and Structure-Activity Relationship

    Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local ...

    4.2K views
    8.2 : Local Anesthetics: Mechanism of Action01:23

    8.2 : Local Anesthetics: Mechanism of Action

    Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of ...

    2.2K views
    8.3 : Local Anesthetics: Pharmacokinetics01:13

    8.3 : Local Anesthetics: Pharmacokinetics

    The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, ...

    733 views
    8.4 : Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

    8.4 : Local Anesthetics: Differential Sensitivity of Nerve Fibers

    Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of ...

    772 views
    8.5 : Local Anesthetics: Common Agents and Their Applications01:23

    8.5 : Local Anesthetics: Common Agents and Their Applications

    Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, ...

    406 views
    8.6 : Local Anesthetics: Adverse Effects01:12

    8.6 : Local Anesthetics: Adverse Effects

    While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can ...

    389 views
    8.7 : Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

    8.7 : Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

    Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the ...

    971 views
    8.8 : Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

    8.8 : Local Anesthetics: Clinical Application as Spinal Anesthesia

    Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar ...

    583 views
    8.9 : Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

    8.9 : Local Anesthetics: Clinical Application as Epidural Anesthesia

    Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for ...

    413 views
    8.10 : Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

    8.10 : Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

    Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained ...

    362 views
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