Branden S. Moriarity

Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.

Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR.

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.

Modular assembly of transposon integratable multigene vectors using RecWay assembly.

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.

Simple and efficient methods for enrichment and isolation of endonuclease modified cells.

Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.

HomeRun Vector Assembly System: a flexible and standardized cloning system for assembly of multi-modular DNA constructs.

PVT1 dependence in cancer with MYC copy-number increase.

Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia.

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery.

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.

Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma.

Coping with cancer genes altered by copy number.

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress.

RALB provides critical survival signals downstream of Ras in acute myeloid leukemia.

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML.

Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.

Relative importance of β- and γ-actin in primary mouse embryonic fibroblasts.

Prosurvival long noncoding RNA regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3.

Rapid generation of Col7a1 mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells.

A novel role for SALL4 during scar-free wound healing in axolotl.

Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.

CRISPR/Cas9 library screening for drug target discovery.

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity.

Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease.

The Molecular Imaging of Natural Killer Cells.

Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays.

Screen Identifies and Other Genetic Drivers in Human B-cell Lymphoma.

Cancer Gene Discovery Utilizing Sleeping Beauty Transposon Mutagenesis.

Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors.

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas.

HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism.

EditR: A Method to Quantify Base Editing from Sanger Sequencing.

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis.

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy.

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors.

Author Correction: Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors.

CRISPR/Cas9-Mediated Genome Engineering of Primary Human B Cells.

PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma.

Efficient targeted integration directed by short homology in zebrafish and mammalian cells.

C-to-U RNA Editing: From Computational Detection to Experimental Validation.

Implication of ZNF217 in accelerating tumor development and therapeutically targeting ZNF217-induced PI3K-AKT signaling for the treatment of metastatic osteosarcoma.

The S-phase-induced lncRNA promotes cell proliferation by controlling YAP1/Hippo signaling pathway.

Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling.

Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity.

ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis.

Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development.

CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells.

Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments.

Nonviral genome engineering of natural killer cells.

Targeted genome editing for the correction or alleviation of primary Immunodeficiencies.

MultiEditR: The first tool for the detection and quantification of RNA editing from Sanger sequencing demonstrates comparable fidelity to RNA-seq.

A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.

Primary B cell engineering for therapeutic research.

A dominant function of LynB kinase in preventing autoimmunity.

Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy.

Optimization and validation of CAR transduction into human primary NK cells using CRISPR and AAV.

Correction of Fanconi Anemia Mutations Using Digital Genome Engineering.

Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies.

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade.

A Pan-RNase Inhibitor Enabling CRISPR-mRNA Platforms for Engineering of Primary Human Monocytes.

CRISPR-Cas9 base editors and their current role in human therapeutics.

Germline T cell receptor exchange results in physiological T cell development and function.

Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production.

Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions.

Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma.

Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair.

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing.

Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies.

Development and testing of a versatile genome editing application reporter (V-GEAR) system.

Advancing gene targeting for primary immune deficiencies: Adenine base editing of the human IL2RG locus for correction of SCID-X1.

Engineering memory T cells as a platform for long-term enzyme replacement therapy in lysosomal storage disorders.

Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy.

Ablation of FAS confers allogeneic CD3 CAR T cells with resistance to rejection by T cells and natural killer cells.

CAR-T cell targeting three receptors on autoreactive B cells for systemic lupus erythematosus therapy.

A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.

Osteosarcoma: A comprehensive review of model systems and experimental therapies.

Techniques for Validating CRISPR Changes Using RNA-Sequencing Data.

Machine Learning Reveals Amine Type in Polymer Micelles Determines mRNA Binding, Performance for Lung-Selective Delivery.

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial.

Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editing.