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Anhui University

2 ARTICLES PUBLISHED IN JoVE

Biology

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Kangliang Sheng^1,2,3, Yifan Xu^1,2,3, Jian Yang^1,2,3, Huijuan Ren^1,2,3, Ziwei Su^1,2,3, Yongzhong Wang^1,2,3,4

¹School of Life Sciences, Anhui University, ²Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, ³Anhui Key Laboratory of Modern Biomanufacturing, ⁴Institute of Physical Science and Information Technology, Anhui University

Here, we present a protocol to establish the antibiotic-induced pseudo-germ-free dextran sulfate sodium-induced colitis mouse model to investigate the role of gut microbiota in regulating the positive effects of Bacillus cereus on colitis.

Bioengineering

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Huiqian Ding^*1, Min Li^*1, Lin Mao¹, Binggang Li¹, Wenqiao Hui¹, Baowei Zhang¹, Qian Ban¹

¹Anhui University

Here, we present a gene therapy approach that delivers ABE-coated chitosan directly to the bone marrow by intraosseous injection.