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Neuroscience

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Nanyang Technological University

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

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3.6K Views

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06:36 min

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September 1st, 2022

DOI :

10.3791/63460-v

September 1st, 2022

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Youjin Lee*¹^,², Daeho Ryu*³, Saeyeong Jeon³, Yena Lee¹, Yoon Kyung Cho¹, Chang-Hyeon Ji¹^,², Yong-Kweon Kim³^,⁴, Sang Beom Jun¹^,²^,⁵

¹Department of Electronic and Electrical Engineering, Ewha Womans University, ²Graduate Program in Smart Factory, Ewha Womans University, ³Department of Electrical and Computer Engineering, Seoul National University, ⁴Graduate School of Engineering Practice, Seoul National University, ⁵Department of Brain and Cognitive Sciences, Ewha Womans University

Podsumowanie

Here, we present the fabrication method of an optrode system with optical fibers for light delivery and an electrode array for neural recording. In vivo experiments with transgenic mice expressing channelrhodopsin-2 show the feasibility of the system for simultaneous optogenetic stimulation and electrophysiological recording.

Przeglądaj więcej filmów

Optogenetic Modulation

Electrical Neural Recording

LED based System

Light Coupling Efficiency

Microlens Array

Spinal Cord Injury

Parkinson s Disease

Alzheimer s Disease

Wireless System

Low Power Consumption

Surgical Protocol

Anesthetized Mouse

Stereotactic Frame

Precision Screw

Rozdziały w tym wideo

0:04

Introduction

1:13

Preparation of an Optrode Array

1:39

Presurgical Preparation of Animal and Implantation Surgery

3:45

Setting Parameters and Conducting Optogenetic Stimulation, Electrophysiological Recording, and Data Analysis

4:55

Results: Electrophysiological Recording

5:40

Conclusion

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