Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

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8.6K Views

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09:36 min

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February 5th, 2019

DOI :

10.3791/58660-v

February 5th, 2019

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Na Jia*¹, Haoan Wu*², Juanli Duan¹, Chunxue Wei¹, Kaixuan Wang², Yu Zhang ², Xiaohua Mao¹

¹Key Laboratory of Ministry of Education for Developmental Genes & Human Diseases, Institute of Life Sciences and School of Medicine, Southeast University, ²State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials & Devices, School of Biological Science & Medical Engineering, Southeast University

Podsumowanie

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Polyethyleneimine

Iron Oxide Nanoparticles

Small Interfering RNA

Macrophages

Therapy

Diagnosis

Chronic Inflammatory Disorders

Cancers

Super Paramagnetic Iron Oxide Nanoparticles SPIONs

Allylic Acid Modification

Dimercapto Acrylic Acid

Magnetic Separation

Hydrolytic Stability

RNA Delivery System

Rozdziały w tym wideo

0:04

Title

1:00

Polyethyleneimine-Coated Superparamagnetic Iron Oxide Nanoparticle (PEI-SPION) Preparation

3:52

PEI-SPION/small interfering (si) RNA Nanoparticle (NP) Agarose Gel Electrophoresis

5:00

In Vitro RAW264.7 Macrophages Transfection

6:55

Results: Representative Biological Characterization of PEI-SPION and PE-SPION/siRNA NPs

8:51

Conclusion

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