Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

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8.8K Views

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08:52 min

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June 13th, 2018

DOI :

10.3791/57664-v

June 13th, 2018

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Ruoji Zhou¹^,², An Xu¹, Jian Tu¹^,³, Mo Liu¹, Julian A Gingold⁴, Ruiying Zhao¹, Dung-Fang Lee¹^,²^,⁵^,⁶

¹Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, ²Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center UTHealth, ³Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, ⁴Women's Health Institute, Cleveland Clinic Foundation, ⁵Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, ⁶Center for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston

Podsumowanie

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Keywords Li Fraumeni Syndrome

Mesenchymal Stem Cells

Differentiation

Animal Procedure

Rozdziały w tym wideo

0:04

Title

0:47

Differentiation of Li-Fraumeni Syndrome (LFS) Patient-derived Induced Pluripotent Stem Cell (iPSC) to Mesenchymal Stem Cell (MSC) (Days 0 - 28)

2:19

iPSC-derived MSC Maturation (Day 28 - 45) and Differentiation of LFS MSC to Osteoblasts (Day 0 - 24)

4:33

Xenograft In Vivo Tumorigenesis Model Setup

6:39

Results: Representative LFS MSC Differentiation

8:10

Conclusion

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