A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

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7.7K Views

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07:08 min

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October 20th, 2016

DOI :

10.3791/54541-v

October 20th, 2016

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Wendy E. Heywood*¹, Anna Baud*¹, Emily Bliss¹, Ernestas Sirka¹, Jonathan M. Schott², Henrik Zetterberg³, Daniela Galimberti⁴, Neil J. Sebire⁵, Kevin Mills¹

¹Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, ²Dementia Research Centre, Institute of Neurology, University College London, ³Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, ⁴Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, ⁵Great Ormond Street Hospital for Children, University College London

Podsumowanie

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Keywords Targeted Proteomics

Multiplexed Assay

Cerebrospinal Fluid

Neurodegenerative Biomarkers

Apolipoprotein E Isoforms

Rapid And Cost effective

Rozdziały w tym wideo

0:05

Title

1:05

Preparation of Standard Peptides

3:33

LC-MRM Method Development and Data Analysis

5:12

Results: High-throughput, Multiplex CSF Assay for Quantification of Neurodegeneration Markers and Detection of ApoE Isoforms

6:17

Conclusion

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