Core - Pharmacokinetics and Pharmacodynamics

Chapter 1

Pharmacokinetics and Pharmacodynamics: Introduction

1.1 : Biopharmaceutics and Pharmacokinetics: Overview

1.1 : Biopharmaceutics and Pharmacokinetics: Overview

Drugs come in various dosage forms, including solids, liquids, semisolids, or aerosols. These formulations deliver drugs at the site of action, triggering ...

1.2 : Pharmacokinetic Models: Overview

1.2 : Pharmacokinetic Models: Overview

Pharmacokinetic models use mathematical analysis to express a drug's time course in the body. These models can simulate rates of a drug's ...

1.3 : Drug Concentration Versus Time Correlation

1.3 : Drug Concentration Versus Time Correlation

Plasma drug levels, plotted at regular intervals, help track its time course in the body. For instance, consider a plot after a single oral dose. The drug ...

1.4 : Drug Concentrations: Measurements

1.4 : Drug Concentrations: Measurements

Drug concentration represents the drug amount present in a biological sample. It helps assess the initial drug pharmacokinetics in the body. The samples ...

1.5 : Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs

1.5 : Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs

Pharmacokinetic models view drugs within the body as dynamic entities and rely on calculus as a vital tool for quantitative drug movement analysis. ...

1.6 : Fundamental Mathematical Principles in Pharmacokinetics: Mathematical Expressions and Units

1.6 : Fundamental Mathematical Principles in Pharmacokinetics: Mathematical Expressions and Units

Mathematical expressions help understand pharmacokinetic parameters by using equations to describe the relationships between different variables. For ...

1.7 : Fundamental Mathematical Principles in Pharmacokinetics: Rate and Order of Reaction

1.7 : Fundamental Mathematical Principles in Pharmacokinetics: Rate and Order of Reaction

Pharmacokinetic models incorporate reaction order and rate to comprehend processes such as drug absorption and elimination. In pharmacokinetics, the rate ...

1.8 : Analysis of Population Pharmacokinetic Data

1.8 : Analysis of Population Pharmacokinetic Data

Traditional pharmacokinetic methods involve taking multiple samples from a few individuals and estimating pharmacokinetic parameters. Despite their common ...

1.9 : Pharmacodynamics: Overview and Principles

1.9 : Pharmacodynamics: Overview and Principles

Pharmacodynamics is the scientific study that explores the biochemical, cellular, and physiological effects of drugs on the body. Most drug effects result ...

1.10 : Structure-Activity Relationships and Drug Design

1.10 : Structure-Activity Relationships and Drug Design

Drug design involves discovering new medications based on specific biological targets. It relies on structure-activity relationships, SAR, or quantitative ...

1.11 : Agonism and Antagonism: Quantification

1.11 : Agonism and Antagonism: Quantification

Administration of drugs can lead to either agonist or antagonist effect. Agonism occurs when a drug activates a receptor, triggering a biological ...

1.12 : Drug Control Governance: Regulatory Bodies and Their Impact

1.12 : Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves global regulatory bodies that standardize and control the safety and efficacy of pharmaceuticals, as well as prevent ...

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