Nondepolarizing neuromuscular blockers induce paralysis by competitively blocking nicotinic acetylcholine receptors at the muscle end plate. Examples include pancuronium, mivacurium, vecuronium, and rocuronium. These quaternary ammonium derivatives are administered intravenously, are poorly absorbed, and are excreted via the kidneys.
Competitive antagonists prevent acetylcholine from binding to its receptor, inhibiting membrane depolarization. Without conformational changes or intrinsic activity, ion channels remain closed, blocking neuromuscular transmission and causing muscle relaxation.
The antagonistic effect can be overcome by increasing acetylcholine concentration using acetylcholinesterase (AChE) inhibitors. Elevated acetylcholine displaces the blocker, restoring neuromuscular transmission. However, the blockers can directly block Na+ channels at high doses, resulting in irreversible neuromuscular blockade unresponsive to AChE inhibitors.
章から 7:
Now Playing
骨格筋弛緩薬
1.2K 閲覧数
骨格筋弛緩薬
2.7K 閲覧数
骨格筋弛緩薬
2.3K 閲覧数
骨格筋弛緩薬
346 閲覧数
骨格筋弛緩薬
408 閲覧数
骨格筋弛緩薬
1.0K 閲覧数
骨格筋弛緩薬
280 閲覧数
骨格筋弛緩薬
600 閲覧数
骨格筋弛緩薬
307 閲覧数
骨格筋弛緩薬
432 閲覧数
骨格筋弛緩薬
828 閲覧数
骨格筋弛緩薬
3.0K 閲覧数
骨格筋弛緩薬
564 閲覧数
Copyright © 2023 MyJoVE Corporation. All rights reserved