quantitative-polymerase-chain-reaction-qpcr-based-rapid-diagnosis

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of <em>Helicobacter pylori</em> Infection and Antibiotic Resistance

Helicobacter pylori is a major human pathogen that&#160;infects approximately half of the global population and is becoming a serious health threat due to ...

Southern Medical University

The use of prasugrel in patients with coronary artery disease (CAD) has been associated with decreased major adverse cardiac events (MACEs) compared with clopidogrel but with an increased risk of bleeding. However, it remains unclear if the risks of bleeding outweigh those of MACEs in patients on prasugrel treatment. We systematically reviewed randomized controlled trials comparing prasugrel with clopidogrel in patients with CAD. We performed a literature search of PubMed, EMBASE, and Cochrane Central Register of Controlled Trial databases from inception to November 25, 2014, and reviewed the reference lists of retrieved articles. A comparative estimate was made for the combined rates of MACEs and bleeding from the same trials in the framework of this meta-analysis and expressed as odds ratios (ORs) and 95% confidence intervals (CIs) in both random- and fixed-effects models. Nine studies involving 25,214 patients were included in our meta-analysis. In both the random- and fixed-effects models, the risks of MACEs outweighed those of major bleeding (OR 7.48, 95% CI 3.75 to 14.94, p <0.0001, random effects) and of minor bleeding (OR 3.77, 95% CI 1.73 to 8.22, p = 0.009, random effects). Results were corroborated in a standard-dose clopidogrel subgroup analysis (OR 7.46, 95% CI 3.54 to 15.68, p <0.0001, and OR 6.44, 95% CI 2.80 to 14.80, p <0.0001, random effects, respectively). In conclusion, despite the increased risk of bleeding associated with prasugrel treatment compared with clopidogrel, the risk of MACEs far outweighed the risk of bleeding.

Meta-Analysis of Randomized Controlled Trials Comparing Risk of Major Adverse Cardiac Events and Bleeding in Patients With Prasugrel Versus Clopidogrel.

To explore the relations among apolipoprotein E4, Tau protein and glycogen synthase kinase 3β (GSK-3β).

[ApoE4 increases glycogen synthase kinase 3β expression and Tau phosphorylation in U87 cells].

To investigate the effect of detector performance during digital breast tomography (DBT) projection data acquisition on reconstructed image quality.

[Influence of projection data correction on digital breast tomosynthesis imaging].

In clinical cerebral perfusion CT examination, repeated scanning the region of interest in the cine mode increases the radiation dose of the patients, while decreasing the radiation dose by lowering the scanning current results in poor image quality and affects the clinical diagnosis. We propose a penalized weighted least-square (PWLS) method for recovering the projection data to improve the quality of low-dose cerebral perfusion CT imaged. This method incorporates the statistical distribution characteristics of brain perfusion CT projection data and uses the statistical properties of the projection data for modeling. The PWLS method was used to recover the data, and the Gauss-Seidel (GS) method was employed for iterative solving. Adaptive weighting is introduced between the original projection data and the projection data after PWLS restoration. The experimental results on the clinical data demonstrated that the PWLS-based sinogram restoration method improved noise reduction and artifact suppression as compared with the conventional noise reduction methods, and better retained the edges and details to generate better cerebral perfusion maps.

Xin-Yu Zhang

Laboratory Medicine,
Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences),
Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences)

Southern Medical University

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance

Xin-Yu Zhang

Laboratory Medicine,Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences),Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences)

Southern Medical University

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance

Laboratory Medicine,
Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences),
Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences)