JoVE Logo

S'identifier

6.14 : Clearance Models: Compartment Models

Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume of distribution (Vss). If absorption is quicker than elimination for oral drugs, the terminal rate constant signifies elimination. Conversely, if absorption is slower, the rate constant indicates absorption.

The two-compartment model effectively represents the pharmacokinetics of less polar drugs distributed into a poorly blood-perfused compartment. This model accurately predicts the pharmacokinetics of the antibiotic vancomycin (Vancocin). Distributional clearance denotes clearance between two compartments: the central compartment, encompassing plasma and well-perfused organs, and the peripheral compartment, housing less-perfused organs.

Understanding these models and factors will help optimize drug dosing and minimize potential side effects.

Tags

Clearance ModelsPharmacokineticsOne compartment ModelTwo compartment ModelDrug EliminationPlasma ClearanceAminoglycoside AntibioticsVancomycinTerminal Rate ConstantVolume Of DistributionDistributional ClearanceDrug Dosing Optimization

Du chapitre 6:

article

Now Playing

6.14 : Clearance Models: Compartment Models

Pharmacokinetics: Drug Excretion and Clearance

56 Vues

article

6.1 : Drug Elimination: Overview

Pharmacokinetics: Drug Excretion and Clearance

1.3K Vues

article

6.2 : Elimination Kinetics: First-Order and Zero-Order

Pharmacokinetics: Drug Excretion and Clearance

529 Vues

article

6.3 : Renal Drug Excretion: Overview

Pharmacokinetics: Drug Excretion and Clearance

131 Vues

article

6.4 : Renal Drug Excretion: Glomerular Filtration

Pharmacokinetics: Drug Excretion and Clearance

201 Vues

article

6.5 : Renal Drug Excretion: Tubular Reabsorption

Pharmacokinetics: Drug Excretion and Clearance

133 Vues

article

6.6 : Renal Drug Excretion: Tubular Secretion

Pharmacokinetics: Drug Excretion and Clearance

152 Vues

article

6.7 : Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa

Pharmacokinetics: Drug Excretion and Clearance

143 Vues

article

6.8 : Hepatic Drug Excretion: Enterohepatic Cycling

Pharmacokinetics: Drug Excretion and Clearance

1.2K Vues

article

6.9 : Hepatic Drug Excretion: Influencing Factors

Pharmacokinetics: Drug Excretion and Clearance

98 Vues

article

6.10 : Drug Excretion: Pulmonary and Glandular Routes

Pharmacokinetics: Drug Excretion and Clearance

90 Vues

article

6.11 : Drug Excretion: Miscellaneous Routes

Pharmacokinetics: Drug Excretion and Clearance

50 Vues

article

6.12 : Drug Clearance: Overview

Pharmacokinetics: Drug Excretion and Clearance

62 Vues

article

6.13 : Clearance Models: Physiological Models

Pharmacokinetics: Drug Excretion and Clearance

53 Vues

article

6.15 : Clearance Models: Noncompartmental Models

Pharmacokinetics: Drug Excretion and Clearance

46 Vues

See More

JoVE Logo

Confidentialité

Conditions d'utilisation

Politiques

Recherche

Enseignement

À PROPOS DE JoVE

Copyright © 2025 MyJoVE Corporation. Tous droits réservés.