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Core - Analytical Chemistry

    Chapter 6

    Principles of Mass Spectrometry

    6.1 : Mass Spectrometry: Overview01:19

    6.1 : Mass Spectrometry: Overview

    Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass ...

    4.6K views
    6.2 : Mass Spectrometry: Isotope Effect01:13

    6.2 : Mass Spectrometry: Isotope Effect

    Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of ...

    2.0K views
    6.3 : Mass Spectrometry: Molecular Fragmentation Overview01:20

    6.3 : Mass Spectrometry: Molecular Fragmentation Overview

    The ionization of a molecule into a molecular ion inside the mass spectrometer causes instability in the molecule's structure due to the loss of an ...

    2.9K views
    6.4 : Mass Spectrometers01:16

    6.4 : Mass Spectrometers

    This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record ...

    5.2K views
    6.5 : Mass Spectrum01:23

    6.5 : Mass Spectrum

    A mass spectrum is the graphical representation of the relative abundance of the charged fragments in an analyte plotted against their mass-to-charge ...

    1.8K views
    6.6 : Mass Spectrum: Interpretation01:24

    6.6 : Mass Spectrum: Interpretation

    Given a known molecular ion mass, the unknown compound can be identified. The empirical formula is determined from the molecular ion mass and the isotope ...

    1.1K views
    6.7 : Mass Analyzers: Overview01:13

    6.7 : Mass Analyzers: Overview

    Common mass analyzers include magnetic sector, double-focusing, quadrupole, time-of-flight, and ion trap analyzers. The capability of any mass analyzer ...

    599 views
    6.8 : Mass Analyzers: Common Types01:19

    6.8 : Mass Analyzers: Common Types

    The quadrupole mass analyzer consists of four parallel rods, across which are applied a DC voltage and a radio-frequency AC voltage. Here, the field ...

    574 views
    6.9 : High-Resolution Mass Spectrometry (HRMS)01:15

    6.9 : High-Resolution Mass Spectrometry (HRMS)

    The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the ...

    1.3K views
    6.10 : Mass Spectrometry: Complex Analysis01:21

    6.10 : Mass Spectrometry: Complex Analysis

    The analysis of complex mixtures requires the combination of separation methods and mass spectrometry in sequence, termed hyphenated methods. GC–MS ...

    726 views
    6.11 : Tandem Mass Spectrometry01:21

    6.11 : Tandem Mass Spectrometry

    Tandem mass spectrometry, or MS/MS, combines two mass analyzers in sequence, connected by a collision or interaction cell. First, the samples are ionized ...

    914 views
    6.12 : Gas Chromatography–Mass Spectrometry (GC–MS)01:14

    6.12 : Gas Chromatography–Mass Spectrometry (GC–MS)

    Gas chromatography–mass spectrometry (GC–MS) is the combination of analytical techniques of gas chromatography and mass spectrometry in a ...

    4.0K views
    6.13 : Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

    6.13 : Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

    Inductively coupled plasma–mass spectrometry, or ICP–MS, uses an ICP source to prepare samples for atomic mass spectrometry. Solution-state ...

    650 views
    6.14 : Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

    6.14 : Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

    Despite the advantages offered by ICP–MS, accurate elemental analysis is affected by spectroscopic and non-spectroscopic interferences. ...

    403 views
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