6.17 : Drugs Affecting Neurotransmitter Release or Uptake
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking neurotransmitter release and uptake by targeting the catecholamine transporter NET. It can also enter synaptic vesicles and displace noradrenaline. Some other drugs like duloxetine, imipramine, and cocaine also inhibit this transporter. Cocaine, in particular, enhances sympathetic activity by obstructing the reuptake of catecholamines. While these drugs have been studied experimentally, only a few have been used clinically. Newer and more selective drugs have made some of these compounds outdated. However, understanding how these drugs affect the release and reuptake of catecholamines is essential for potential treatments of various disorders.
Del capítulo 6:
Now Playing
6.17 : Drugs Affecting Neurotransmitter Release or Uptake
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
886 Vistas
6.1 : Neuronas Adrenúdicas: Neurotransmisión
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
3.2K Vistas
6.2 : Receptores Adrenérgicos (Adrenoceptores): Clasificación
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
2.1K Vistas
6.3 : Receptores adrenérgicos: ɑ Subtipo
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
1.3K Vistas
6.4 : Receptores adrenérgicos: subtipo β
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
1.4K Vistas
6.5 : Agonistas adrenérgicos: agentes de acción directa
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
1.3K Vistas
6.6 : Agonistas adrenérgicos: agentes de acción indirecta
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
1.4K Vistas
6.7 : Agonistas adrenérgicos: agentes de acción mixta
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
631 Vistas
6.8 : Agonistas adrenérgicos: química y relación estructura-actividad
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
2.5K Vistas
6.9 : Agonistas adrenérgicos: clasificación terapéutica
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
650 Vistas
6.10 : Agonistas adrenérgicos: usos terapéuticos
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
693 Vistas
6.11 : Antagonistas adrenérgicos: química y clasificación de los bloqueadores de los receptores ɑ
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
767 Vistas
6.12 : Antagonistas Adrenérgicos: Acciones Farmacológicas de los Bloqueadores de los Receptores ɑ
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
514 Vistas
6.13 : Antagonistas adrenérgicos: química y clasificación de los bloqueadores de los receptores de β
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
472 Vistas
6.14 : Antagonistas Adrenérgicos: Acciones Farmacológicas de los Bloqueadores de los Receptores β
Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents
501 Vistas
See More
ACERCA DE JoVE
Copyright © 2025 MyJoVE Corporation. Todos los derechos reservados