Chapter 6
Principles of Mass Spectrometry
Espectrometría de masas: descripción general
Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass ...
Espectrometría de masas: efecto isotópico
Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of ...
Espectrometría de masas: descripción general de la fragmentación molecular
The ionization of a molecule into a molecular ion inside the mass spectrometer causes instability in the molecule's structure due to the loss of an ...
Espectrómetros de masas
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record ...
Espectro de masas
A mass spectrum is the graphical representation of the relative abundance of the charged fragments in an analyte plotted against their mass-to-charge ...
Espectro de masas: interpretación
Given a known molecular ion mass, the unknown compound can be identified.
The empirical formula is determined from the molecular ion mass and the isotope ...
Analizadores de masas: descripción general
Common mass analyzers include magnetic sector, double-focusing, quadrupole, time-of-flight, and ion trap analyzers.
The capability of any mass analyzer ...
Analizadores de masas: tipos comunes
The quadrupole mass analyzer consists of four parallel rods, across which are applied a DC voltage and a radio-frequency AC voltage.
Here, the field ...
Espectrometría de masas de alta resolución (HRMS)
The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the ...
Espectrometría de Masas: Análisis Complejo
The analysis of complex mixtures requires the combination of separation methods and mass spectrometry in sequence, termed hyphenated methods.
GC–MS ...
Espectrometría de masas en tándem
Tandem mass spectrometry, or MS/MS, combines two mass analyzers in sequence, connected by a collision or interaction cell.
First, the samples are ionized ...
Cromatografía de gases-espectrometría de masas (GC-MS)
Gas chromatography–mass spectrometry (GC–MS) is the combination of analytical techniques of gas chromatography and mass spectrometry in a ...
Espectrometría de masas con plasma acoplado inductivamente (ICP-MS): descripción general
Inductively coupled plasma–mass spectrometry, or ICP–MS, uses an ICP source to prepare samples for atomic mass spectrometry.
Solution-state ...
Espectrometría de masas de plasma acoplado inductivamente (ICP-MS): Interferencias
Despite the advantages offered by ICP–MS, accurate elemental analysis is affected by spectroscopic and non-spectroscopic interferences.
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