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Core - Pharmacokinetics and Pharmacodynamics

    Chapter 4

    Pharmacokinetics: Drug Distribution and Protein Binding

    4.1 : Drug Distribution: Overview01:11

    4.1 : Drug Distribution: Overview

    Distribution refers to the two-way movement of a drug between different compartments within the body. It is a passive process driven by the concentration ...

    140 views
    4.2 : Factors Affecting Drug Distribution: Tissue Permeability01:30

    4.2 : Factors Affecting Drug Distribution: Tissue Permeability

    Drug distribution across biological membranes to target tissues relies on the drug's physicochemical properties, such as molecular size, ionization ...

    148 views
    4.3 : Factors Affecting Drug Distribution: Physiological Barriers01:23

    4.3 : Factors Affecting Drug Distribution: Physiological Barriers

    Drug distribution is governed by several physiological barriers. The simple capillary endothelial barrier limits the passage of drugs larger than 600 ...

    176 views
    4.4 : Factors Affecting Drug Distribution: Organ Perfusion Rate01:15

    4.4 : Factors Affecting Drug Distribution: Organ Perfusion Rate

    Drug distribution can be perfusion rate-limited, particularly when the drug is highly lipophilic, and the membrane to cross is highly permeable. The ...

    100 views
    4.5 : Factors Affecting Drug Distribution: Miscellaneous Factors01:19

    4.5 : Factors Affecting Drug Distribution: Miscellaneous Factors

    Drug distribution can be affected by various factors. It can vary with age due to differences in body composition. For instance, older adults have less ...

    270 views
    4.6 : Volume of Distribution01:20

    4.6 : Volume of Distribution

    The apparent volume of distribution or Vd is a key pharmacokinetic parameter signifying the hypothetical body fluid volume into which a drug disperses. It ...

    127 views
    4.7 : Protein-Drug Binding: Mechanism and Kinetics01:16

    4.7 : Protein-Drug Binding: Mechanism and Kinetics

    Protein-drug binding is the interaction between drugs and proteins in the body. It can be either intracellular binding, which involves drug interactions ...

    301 views
    4.8 : Drug Binding to Blood Components01:30

    4.8 : Drug Binding to Blood Components

    When drugs enter the systemic circulation, they interact with blood components like human serum albumin or HSA, α1-acid glycoprotein or AAG, ...

    112 views
    4.9 : Tissue-Drug Binding: Localization of Drugs and its Significance01:24

    4.9 : Tissue-Drug Binding: Localization of Drugs and its Significance

    Body tissues comprise 40-90% of body weight depending on body composition. They can serve as drug storage sites, competing with plasma binding sites. ...

    67 views
    4.10 : Protein-Drug Binding: Determination Methods01:22

    4.10 : Protein-Drug Binding: Determination Methods

    Protein-drug binding is determined through indirect and direct methods. Indirect methods involve isolating the bound drug from its free form in biological ...

    132 views
    4.11 : Factors Affecting Protein-Drug Binding: Drug-Related Factors01:18

    4.11 : Factors Affecting Protein-Drug Binding: Drug-Related Factors

    Protein-drug binding can be affected by various drug-related factors. The degree of protein binding is closely related to a drug's lipophilicity, with ...

    83 views
    4.12 : Factors Affecting Protein-Drug Binding: Protein-Related Factors01:20

    4.12 : Factors Affecting Protein-Drug Binding: Protein-Related Factors

    Drug binding to proteins depends on various factors, including physicochemical properties, protein concentration, disease states, and the number of ...

    124 views
    4.13 : Factors Affecting Protein-Drug Binding: Drug Interactions01:23

    4.13 : Factors Affecting Protein-Drug Binding: Drug Interactions

    Drug displacement interactions arise when drugs compete for the same binding site, leading to displacement. The extent of displacement depends on the ...

    105 views
    4.14 : Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

    4.14 : Factors Affecting Protein-Drug Binding: Patient-Related Factors

    Protein-drug binding varies with many patient-related factors. Age impacts binding due to varying protein content in different age groups. Neonates ...

    38 views
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