Jordan J. Green

Nanoengineering approaches to the design of artificial antigen-presenting cells.

Biodegradable polymeric vectors for gene delivery to human endothelial cells.

Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells.

A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery.

Nanoparticles for gene transfer to human embryonic stem cell colonies.

Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.

Poly(beta-amino esters): procedures for synthesis and gene delivery.

Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery.

Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice.

Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles.

Tissue-specific gene delivery via nanoparticle coating.

Degradable polymers for gene delivery.

Electrostatic surface modifications to improve gene delivery.

The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures.

Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis.

Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma.

Poly(β-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studies.

Effects of base polymer hydrophobicity and end-group modification on polymeric gene delivery.

A novel assay for quantifying the number of plasmids encapsulated by polymer nanoparticles.

Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cells.

Gene delivery nanoparticles specific for human microvasculature and macrovasculature.

Therapeutic angiogenesis using genetically engineered human endothelial cells.

2011 Rita Schaffer lecture: nanoparticles for intracellular nucleic acid delivery.

Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo.

Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery.

Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation.

Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties.

Subtle Changes to Polymer Structure and Degradation Mechanism Enable Highly Effective Nanoparticles for siRNA and DNA Delivery to Human Brain Cancer.

siRNA nanomedicine: the promise of bioreducible materials.

Poly(beta-aminoester) nanoparticle-delivery of p53 has activity against small cell lung cancer in vitro and in vivo.

Student award winner in the Ph.D. category for the 2013 society for biomaterials annual meeting and exposition, april 10-13, 2013, Boston, Massachusetts : biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using synthetic poly(beta-amino ester)s.

The effect and role of carbon atoms in poly(β-amino ester)s for DNA binding and gene delivery.

A bioreducible linear poly(β-amino ester) for siRNA delivery.

(3-aminopropyl)-4-methylpiperazine end-capped poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based multilayer films for gene delivery.

Bioengineered nanoparticles for siRNA delivery.

Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide.

Independent vs. Cooperative Binding in Polyethylenimine-DNA and Poly(L-lysine)-DNA Polyplexes.

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells.

Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine.

Differential polymer structure tunes mechanism of cellular uptake and transfection routes of poly(β-amino ester) polyplexes in human breast cancer cells.

Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells.

Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells.

Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo.

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.

Highlights from the latest articles in nanomedicine.

Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.

Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA.

An automated multidimensional thin film stretching device for the generation of anisotropic polymeric micro- and nanoparticles.

Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.

Shaping the future of nanomedicine: anisotropy in polymeric nanoparticle design.

Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells.

Targeted polymeric nanoparticles for cancer gene therapy.

Gene delivery polymer structure-function relationships elucidated via principal component analysis.

Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.

Bioreducible Poly(Beta-Amino Ester)s for Intracellular Delivery of SiRNA.

Layer-by-layer inorganic/polymeric nanoparticles for kinetically controlled multigene delivery.

Biodegradable polymer iron oxide nanocomposites: the future of biocompatible magnetism.

Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain.

Quantification of cellular and nuclear uptake rates of polymeric gene delivery nanoparticles and DNA plasmids via flow cytometry.

Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours.

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

Non-viral nucleic acid containing nanoparticles as cancer therapeutics.

Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy.

Gene delivery nanoparticles to modulate angiogenesis.

Mimicking biological functionality with polymers for biomedical applications.

Noninvasive Targeted Transcranial Neuromodulation via Focused Ultrasound Gated Drug Release from Nanoemulsions.

Tyrosine kinase blocking collagen IV-derived peptide suppresses ocular neovascularization and vascular leakage.

Continuous microfluidic assembly of biodegradable poly(beta-amino ester)/DNA nanoparticles for enhanced gene delivery.

Nanoparticle Tracking Analysis for Determination of Hydrodynamic Diameter, Concentration, and Zeta-Potential of Polyplex Nanoparticles.

Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing.

Polymeric nanoparticles as cancer-specific DNA delivery vectors to human hepatocellular carcinoma.

A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery.

Surface engineering for lymphocyte programming.

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy.

Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinoma.

Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple-negative breast cancer cells.

Nanoscale artificial antigen presenting cells for cancer immunotherapy.

Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments.

Anisotropic biodegradable lipid coated particles for spatially dynamic protein presentation.

Injectable drug depot engineered to release multiple ophthalmic therapeutic agents with precise time profiles for postoperative treatment following ocular surgery.

Bacterial tRNase-Based Gene Therapy with Poly(β-Amino Ester) Nanoparticles for Suppressing Melanoma Tumor Growth and Relapse.

Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival.

Non-Viral Delivery To Enable Genome Editing.

Enhancing oligodendrocyte differentiation by transient transcription activation via DNA nanoparticle-mediated transfection.

Entanglement-Based Thermoplastic Shape Memory Polymeric Particles with Photothermal Actuation for Biomedical Applications.

Verteporfin-Loaded Poly(ethylene glycol)-Poly(beta-amino ester)-Poly(ethylene glycol) Triblock Micelles for Cancer Therapy.

Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection.

Polymeric micro- and nanoparticles for immune modulation.

Differentially Branched Ester Amine Quadpolymers with Amphiphilic and pH-Sensitive Properties for Efficient Plasmid DNA Delivery.

The role of assembly parameters on polyplex poly(beta-amino ester) nanoparticle transfections.

A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling.

Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing.

Verteporfin-Loaded Polymeric Microparticles for Intratumoral Treatment of Brain Cancer.

Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.

Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo.

Polymeric Nucleic Acid Delivery for Immunoengineering.

Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery.

Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types.

Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization.

Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours.

Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.

Carboxylated branched poly(β-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing.

Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics.

In situ genetic engineering of tumors for long-lasting and systemic immunotherapy.

A Sox2:miR-486-5p Axis Regulates Survival of GBM Cells by Inhibiting Tumor Suppressor Networks.

Themed issue on nanoscale biomaterials.

Poly(Beta-Amino Ester) Nanoparticles Enable Nonviral Delivery of CRISPR-Cas9 Plasmids for Gene Knockout and Gene Deletion.

Biomimetic anisotropic polymeric nanoparticles coated with red blood cell membranes for enhanced circulation and toxin removal.

Biomimetic tolerogenic artificial antigen presenting cells for regulatory T cell induction.

Gene delivery for immunoengineering.

Immunoengineering has arrived.

Non-viral gene delivery of HIF-1α promotes angiogenesis in human adipose-derived stem cells.

Safety considerations for nanoparticle gene delivery in pediatric brain tumors.

Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities.

Suprachoroidal gene transfer with nonviral nanoparticles.

Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases.

Efficiency of Cytosolic Delivery with Poly(β-amino ester) Nanoparticles is Dependent on the Effective p of the Polymer.

Poly(ethylene glycol)-Poly(beta-amino ester)-Based Nanoparticles for Suicide Gene Therapy Enhance Brain Penetration and Extend Survival in a Preclinical Human Glioblastoma Orthotopic Xenograft Model.

Biodegradable Cationic Polymer Blends for Fabrication of Enhanced Artificial Antigen Presenting Cells to Treat Melanoma.

A combinatorial library of biodegradable polyesters enables non-viral gene delivery to post-mitotic human stem cell-derived polarized RPE monolayers.

Overcoming delivery barriers in immunotherapy for glioblastoma.

High-throughput evaluation of polymeric nanoparticles for tissue-targeted gene expression using barcoded plasmid DNA.

HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.

Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer.

Size-Controlled and Shelf-Stable DNA Particles for Production of Lentiviral Vectors.

High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications.

Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy.

Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies.

Recent Advances in Gene Therapy for Cancer Theranostics.

Nanoparticles for generating antigen-specific T cells for immunotherapy.

High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA.

Toward Gene Transfer Nanoparticles as Therapeutics.

Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications.

PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients.

The endosomal pH regulator NHE9 is a driver of stemness in glioblastoma.

ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization.

Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma.

Approaches towards biomaterial-mediated gene editing for cancer immunotherapy.

Poly(Beta-Amino Ester)s as High-Yield Transfection Reagents for Recombinant Protein Production.

Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications.

Machine learning guided structure function predictions enable in silico nanoparticle screening for polymeric gene delivery.

Verteporfin-loaded microparticles for radiosensitization of preclinical lung and breast metastatic spine cancer.

Shape matters: Biodegradable anisotropic nanoparticle artificial antigen presenting cells for cancer immunotherapy.

Anti-angiogenic collagen IV-derived peptide target engagement with αβ and αβ in ocular neovascularization models.

Non-Viral Gene Delivery to Hepatocellular Carcinoma via Intra-Arterial Injection.

Improvement of Islet Engrafts via Treg Induction Using Immunomodulating Polymeric Tolerogenic Microparticles.

Bioengineered particles expand myelin-specific regulatory T cells and reverse autoreactivity in a mouse model of multiple sclerosis.

Polymeric nanoparticle gel for intracellular mRNA delivery and immunological reprogramming of tumors.

Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination.

A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity.

Biodegradable Polyester Nanoparticle Vaccines Deliver Self-Amplifying mRNA in Mice at Low Doses.

Biomaterial-Mediated Genetic Reprogramming of Merkel Cell Carcinoma and Melanoma Leads to Targeted Cancer Cell Killing and .

BME 2.0: Engineering the Future of Medicine.

Erratum to "BME 2.0: Engineering the Future of Medicine".

An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2.

Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity.

Suprachoroidal gene transfer with nonviral nanoparticles in large animal eyes.

Phase 1, Dose Escalation, Nonrandomized, Open-Label, Clinical Trial Evaluating the Safety and Preliminary Efficacy of Allogenic Adipose-Derived Mesenchymal Stem Cells for Recurrent Glioblastoma: A Clinical Trial Protocol.

The cytokine Meteorin-like inhibits anti-tumor CD8 T cell responses by disrupting mitochondrial function.

Supramolecular assembly of polycation/mRNA nanoparticles and in vivo monocyte programming.

Ligand-free biodegradable poly(beta-amino ester) nanoparticles for targeted systemic delivery of mRNA to the lungs.

Alginate-based artificial antigen presenting cells expand functional CD8 T cells with memory characteristics for adoptive cell therapy.

Highly Multiplexed Immunofluorescence PhenoCycler Panel for Murine Formalin-Fixed Paraffin-Embedded Tissues Yields Insight Into Tumor Microenvironment Immunoengineering.

Therapeutic potential and impact of nanoengineered patient-derived mesenchymal stem cells in a murine resection and recurrence model of human glioblastoma.

Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants.

Biomimetic Anisotropic-Functionalized Platelet-Membrane-Coated Polymeric Particles for Targeted Drug Delivery to Human Breast Cancer Cells.

Suprachoroidal Delivery of Viral and Nonviral Vectors for Treatment of Retinal and Choroidal Vascular Diseases.

miR-217-5p NanomiRs Inhibit Glioblastoma Growth and Enhance Effects of Ionizing Radiation via EZH2 Inhibition and Epigenetic Reprogramming.

Nanoparticle Targeting Strategies for Lipid and Polymer-Based Gene Delivery to Immune Cells In Vivo.

Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival.