Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
5.8K Views
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08:16 min
•
October 6th, 2022
DOI :
October 6th, 2022
•Hannah E. Korah1, Kevin Cheng1, Stephanie M. Washington2, Matthew E. Flowers1, Harrison J. Stratton1, Amol Patwardhan5, Mohab M. Ibrahim*1,2,3,4, Laurent F. Martin*1,2
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, 2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, 3Neuroscience Graduate Interdisciplinary Program, College of Medicine, The University of Arizona, Tucson, 4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, 5Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center
Chapters in this video
0:05
Introduction
0:57
First Step: Measure the Baseline of Mechanical Sensitivity Using the Von Frey Test
1:53
Second Step: Measure the Baseline of Thermal Sensitivity Using the Hargreaves Test
2:41
Measuring the Baseline of Thermal Sensitivity Using the Hot Plate Test
3:47
Preoperative Preparation
4:30
Surgical Procedure and Postsurgical Behavioral Tests
6:38
Results: Dose‐Dependent Reversal of pSNL‐Induced Mechanical Hypersensitivity by Intraperitoneal Injection of Morphine or Ibuprofen
7:36
Conclusion
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