Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
3.1K Views
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09:17 min
•
March 1st, 2022
DOI :
March 1st, 2022
•1Beijing Computational Science Research Center, 2Shenzhen JL Computational Science and Applied Research Institute, 3School of Medical Informatics and Engineering, Xuzhou Medical University, 4Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 5Department of Physics and Astronomy, University of California, Irvine, 6Department of Chemistry, University of California, Irvine, 7NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine
Chapters in this video
0:04
Introduction
0:45
Construction of the Markov State Model from Atomic Molecular Dynamics Simulations
6:26
Conducting Coarse-Grained Simulation to Sample Long-Time Dynamics
6:57
Results: Structure-Based Simulation and Sampling of Transcription Factor Protein Movements
8:45
Conclusion
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