Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

3.3K Views

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06:22 min

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April 7th, 2021

DOI :

10.3791/62327-v

April 7th, 2021

•

Martin Russ*¹, Emilia Boerger*¹, Philip von Platen², Roland C. E. Francis¹, Mahdi Taher¹, Willehad Boemke¹, Burkhard Lachmann¹, Steffen Leonhardt², Philipp A. Pickerodt¹

¹Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, ²Chair for Medical Information Technology, RWTH Aachen University

Summary

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Surfactant Depletion

Acute Respiratory Distress Syndrome

ARDS Model

Injurious Ventilation

Recruitability

Mechanical Ventilation

Carbon Dioxide Pressure

Oxygen Saturation

Intravenous Infusion

Muscle Relaxant

Central Venous Catheter

Pulmonary Arterial Catheter

Invasive Blood Pressure Monitoring

Calibration Transducers

Pulmonary Capillary Wedge Pressure

Respiratory Settings

Chapters in this video

0:05

Introduction

0:44

The Mechanical Ventilation

1:46

Introduction of the Pulmonary Artery Catheter

2:46

Surfactant Depletion

3:41

Injurious Ventilation with High Tidal Volume/Low PEEP (High Tv/low PEEP)

4:25

Results: Effects of the Injurious Ventilation on the Lungs

5:40

Conclusion

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