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Behavior

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Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

5.6K Views

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07:41 min

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October 23rd, 2020

DOI :

10.3791/61806-v

October 23rd, 2020

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Kaavya Gudapati*¹^,², Anayesha Singh*¹^,³, Danielle Clarkson-Townsend¹^,⁴, Stephen Q. Phillips¹, Amber Douglass¹, Andrew J. Feola¹^,², Rachael S. Allen¹^,²

¹Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, ²Department of Biomedical Engineering, Georgia Institute of Technology, ³Department of Neuroscience, Emory University, ⁴Gangarosa Department of Environmental Health, Emory University

Summary

Neural degeneration in both eyes and brain as a result of diabetes can be observed through behavioral tests carried out on rodents. The Y-maze, a measure of spatial cognition, and the optomotor response, a measure of visual function, both provide insight into potential diagnoses and treatments.

Explore More Videos

Behavioral Assessment

Visual Function

Optomotor Response

Cognitive Function

Retinal Dysfunction

Brain Dysfunction

Testing Procedures

Spatial Frequency

Virtual Reality Chamber

Innate Responses

Early Diagnosis

Chapters in this video

0:04

Introduction

1:01

Optomotor Response (OMR) Apparatus Setup

2:24

Spatial Frequency Evaluation

3:51

Contrast Sensitivity Evaluation

4:41

Y-Maze Evaluation

5:54

Results: Representative OMR and Y-Maze Analyses of Diabetic Rat Visual and Cognitive Function and Exploratory Behavior Over Time

7:05

Conclusion

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