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Nanyang Technological University

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

10.6K Views

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10:31 min

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April 20th, 2018

DOI :

10.3791/57117-v

April 20th, 2018

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Óscar Julián Arias-Mutis¹^,²^,³, Patricia Genovés¹^,²^,³, Conrado J. Calvo¹^,²^,⁴, Ana Díaz⁵, Germán Parra²^,³, Luis Such-Miquel⁶, Luis Such², Antonio Alberola², Francisco Javier Chorro¹^,³, Manuel Zarzoso⁶

¹CIBERCV, Instituto de Salud Carlos III, ²Department of Physiology, Universitat de València, ³INCLIVA, ⁴Department of Electronic Engineering, Universidad Politécnica de Valencia, ⁵UCIM, Universitat de València, ⁶Department of Physiotherapy, Universitat de València

Summary

We describe methods to develop an experimental model of diet-induced metabolic syndrome (MetS) in rabbits using a high-fat, high-sucrose diet. Animals developed central obesity, mild hypertension, pre-diabetes, and dyslipidemia, thus reproducing the main components of human MetS. This chronic model will allow acquisition of knowledge underlying mechanisms of disease progression.

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Chapters in this video

0:05

Title

0:59

Acclimate Animals for 4 Weeks and Induce MetS for 28 Weeks

2:30

Morphological Assessment

3:48

Fasting Glycemia and Intravenous Glucose Tolerance Test

5:14

Blood Pressure

6:55

Plasma Measurements

7:57

Results: Assessment of Diet-induced Metabolic Syndrome in Rabbits

9:48

Conclusion

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