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    Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo

Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo

8.5K Views

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08:01 min

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September 26th, 2016

DOI :

10.3791/54068-v

September 26th, 2016

•

Joshua R. Biller1,2, Deborah G. Mitchell1, Mark Tseytlin3,4, Hanan Elajaili1, George A. Rinard5, Richard W. Quine6, Sandra S. Eaton1, Gareth R. Eaton1
1Department of Chemistry and Biochemistry, University of Denver, 2Magnetic Imaging Group, Applied Physics Division, Physical Measurements Laboratory, National Institute of Standards and Technology, 3Department of Radiology, Geisel School of Medicine, Dartmouth University, 4Department of Biochemistry, West Virginia University, 5Department of Electrical and Computer Engineering, University of Denver, 6Department of Engineering, University of Denver

A new electron paramagnetic resonance (EPR) method, rapid scan EPR (RS-EPR), is demonstrated for 2D spectral spatial imaging which is superior to the traditional continuous wave (CW) technique and opens new venues for in vivo imaging. Results are demonstrated at 250 MHz, but the technique is applicable at any frequency.

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Rapid scan EPR Imaging
RSEPRI
Electron Paramagnetic Resonance
Oxygen Concentration
PH
Redox Status
Signaling Molecules
Biomedical Research
Cancer Research
Tumor Environment
Continuous Wave EPR
Rapid scan Experimental Conditions
Resonator Bandwidth
Rapid scan Coil Driver
N 15 PDT
BMPO
Hydrogen Peroxide
UV Irradiation

Chapters in this video

0:05

Title

0:58

Setup of the Rapid Scan Coil Driver at 250 MHz

2:01

Preparation of Reagents and Phantoms

3:17

Setup of the Rapid Scan Instrument at 250 MHz

5:58

Results: 2D RS-EPRI Phantom Images

7:12

Conclusion

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