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Neuroscience

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Nanyang Technological University

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

10.9K Views

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09:46 min

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March 8th, 2015

DOI :

10.3791/52457-v

March 8th, 2015

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Tharakeswari Selvakumar¹, Kambiz N. Alavian², Travis Tierney¹

¹Department of Neurosurgery, Brigham & Women's Hospital, Harvard Medical School, ²Division of Brain Sciences, Department of Medicine, Imperial College London

Summary

The mechanism underlying the therapeutic effects of Deep Brain Stimulation (DBS) surgery needs investigation. The methods presented in this manuscript describe an experimental approach to examine the cellular events triggered by DBS by analyzing the gene expression profile of candidate genes that can facilitate neurogenesis post DBS surgery.

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Keywords Gene Expression

Deep Brain Stimulation

Anterior Thalamic Nucleus

Rat Hippocampus

Quantitative RT PCR

Stereotactic Surgery

Chapters in this video

0:05

Title

1:38

Presurgical Preparation

3:04

Deep Brain Stimulation Surgery

6:45

Hippocampus Isolation

7:49

Results: Gene Expression Changes After Deep Brain Stimulation of the Anterior Thalamic Nucleus

8:59

Conclusion

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