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Nanyang Technological University

Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration

8.3K Views

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06:16 min

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May 29th, 2015

DOI :

10.3791/52418-v

May 29th, 2015

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Mark J. Kearns¹, Yingjin Wang³, John H. Boyd²

¹Cardiovascular Surgery, UBC James Hogg Research Center, St. Paul's Hospital, ²Respiratory and Critical Care Medicine, UBC James Hogg Research Center, St. Paul's Hospital, ³UBC James Hogg Research Center, St. Paul's Hospital

Summary

We describe a novel technique for heterotopic abdominal heart-lung transplantation (HAHLT) in rats. The transplant configuration results in a partially loaded graft circulation, allowing direct functional assessment. This model may be employed for acute or chronic studies of function and immunologic status of the transplanted graft.

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Keywords Rat Heterotopic Abdominal Heart single lung Transplantation

Volume loaded Configuration

Donor Inferior Vena Cava To Recipient Inferior Vena Cava Anastomosis

Donor Ascending Aorta To Recipient Abdominal Aorta Anastomosis

Right Upper And Middle Lung Lobes As Conduits

Pressure volume Conductance Catheters

Acute And Chronic Studies

Mixed Venous And Arterial Blood

Technical Complexity

Surgical Training

Chapters in this video

0:05

Title

1:06

Donor Heart-lung Graft Preparation

3:21

Heterotopic Abdominal Heart and Lung Transplantation (HAHLT)

5:21

Results: Representative Baseline and Preload-occlusion Pressure-volume Data

5:51

Conclusion

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