JoVE Journal

Neuroscience

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Nanyang Technological University

A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model

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4.5K Views

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08:58 min

•

June 13th, 2020

DOI :

10.3791/61113-v

June 13th, 2020

•

Megan Rich¹, Quentin Whitsitt¹, Farah Lubin², Mark Bolding¹

¹Department of Radiology, University of Alabama at Birmingham, ²Department of Neurobiology, University of Alabama at Birmingham

Podsumowanie

Focused ultrasound with microbubble agents can open the blood brain barrier focally and transiently. This technique has been used to deliver a wide range of agents across the blood brain barrier. This article provides a detailed protocol for the localized delivery to the rodent brain with or without MRI guidance.

Przeglądaj więcej filmów

Blood brain Barrier

Non invasive Delivery

Stereotactic Frame

T2 Weighted Images

Target Brain Region

Fiducial Measurements

Rozdziały w tym wideo

0:05

Introduction

0:32

Intracranial Targeting Procedure

3:26

Focused Ultrasound Procedure

7:12

Results: Focused Ultrasound BBB Opening

8:43

Conclusion

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