Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

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5.7K Views

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07:05 min

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May 12th, 2019

DOI :

10.3791/59236-v

May 12th, 2019

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Anna Billeschou¹, Jenna Hunt¹, Hannelouise Kissow¹^,²

¹Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, ²Novo Nordisk Foundation Center of Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

Podsumowanie

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Chemotherapy induced Mucositis

Small Intestinal Injury

Proliferative Markers

5 Fluorouracil 5FU

4 Bromo Deoxyuridine BrdU

Intraperitoneal Injection

Laparotomy

Histological Processing

Weight Measurement

Tissue Collection

Image Analysis

BrdU Immunoreactive Cells

Mouse Model

Rozdziały w tym wideo

0:04

Title

0:32

5-Fluorouracil (5-FU) Mucositis Induction

1:09

5-Bromo-2 -Deoxyuridine (BrdU) Quantification and Tissue Collectio

2:42

BrdU Immunoreactive Cell Area Measurement

4:23

Crypt Depth Measurement

4:57

Results: Representative Small Intestine Injury Recovery Assessment

6:17

Conclusion

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