Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

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7.7K Views

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10:16 min

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October 12th, 2018

DOI :

10.3791/58332-v

October 12th, 2018

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Elana Ben-Akiva*¹, Kelly R. Rhodes*¹, Randall A. Meyer¹, Jordan J. Green²

¹Biomedical Engineering, Translational Tissue Engineering Center, Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, ²Biomedical Engineering, Translational Tissue Engineering Center, Institute for Nanobiotechnology, Ophthalmology, Oncology, Neurosurgery, Materials Science and Engineering, Chemical and Biomolecular Engineering, and the Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine

Podsumowanie

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Keywords Anisotropic Polymeric Artificial Antigen Presenting Cells

CD8 T Cell Activation

Particle Physical Properties

Biomaterial Immune Cell Interactions

Micro particle Synthesis

Nano particle Synthesis

Rozdziały w tym wideo

0:04

Title

0:49

Tunable Spherical Poly(Lactic-Co-Glycolic Acid) (PLGA) Fabrication

3:30

Tunable Polymeric Particle Fabrication

6:21

Surface Protein Conjugation for Artificial Antigen Presenting Cell (aAPC) Creation

8:01

Results: Representative Spherical and Ellipsoidal Particle Characterization

9:49

Conclusion

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