JoVE Journal

Bioengineering

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Nanyang Technological University

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

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9.6K Views

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09:04 min

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September 10th, 2018

DOI :

10.3791/58219-v

September 10th, 2018

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Baozhen Zhang¹, Zhilong Chen¹^,², Jinyu Han¹^,³, Mengxia Li¹, Nihar R. Nayak⁴, Xiujun Fan¹

¹Laboratory for Reproductive Health, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, ²College of Veterinary Medicine, Hunan Agricultural University, ³Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion, College of Chemistry and Material Sciences, Heilongjiang University, ⁴Department of Obstetrics and Gynecology, Wayne State University School of Medicine

Podsumowanie

We describe a system that utilizes three methods to evaluate the safety and effectiveness of placenta-targeted drug delivery: in vivo imaging to monitor nanoparticle accumulation, high-frequency ultrasound to monitor placental and fetal development, and HPLC to quantify drug delivery to tissue.

Przeglądaj więcej filmów

Placenta targeted Drug Delivery

In Vivo Fluorescence Imaging

High frequency Ultrasound

Embryonic Development

Intravenous Nanoparticle Injection

Rozdziały w tym wideo

0:04

Title

1:11

In Vivo Fluorescence Imaging

2:35

High-Frequency Ultrasound (HFUS) Embryonic Development Evaluation

4:28

High Pressure Liquid Chromatography (HPLC) Analysis

6:18

Results: Representative Placenta-Targeted Drug Delivery Analyses

8:12

Conclusion

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