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JoVE Journal

Chemistry

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Nanyang Technological University

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

11.0K Views

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13:15 min

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July 18th, 2014

DOI :

10.3791/51874-v

July 18th, 2014

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1Faculty of Pharmacy, University of Sydney, 2Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University

Colloidal probe nanoscopy can be used within a variety of fields to gain insight into the physical stability and coagulation kinetics of colloidal systems and aid in drug discovery and formulation sciences using biological systems. The method described within provides a quantitative and qualitative means to study such systems.

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Keywords Colloidal Probe Nanoscopy
Atomic Force Microscope
Particle particle Interactions
Adhesive Properties
Binding Energies
Physical Stability
Coagulation Kinetics
Colloidal Systems
Emulsions
Foams
Suspensions
Pharmaceuticals
Foods
Paints
Paper
Soil
Minerals
Detergents
Printing
Drug Discovery
Formulation Development

Rozdziały w tym wideo

0:05

Title

2:09

Preparing the Colloidal Probe and Atomic Force Microscope Substrate

4:45

Mounting the Colloidal Probe, Aligning the Laser, and Equilibrating the System

7:25

Imaging, Data Acquisition, and Preparation for Analysis

11:19

Results: Interactions Between Lipid-based Particles and Model Pressurized Metered Dose Inhaler Propellant

12:51

Conclusion

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