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Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase

11.4K Views

10:20 min

June 16th, 2008

DOI :

10.3791/793-v

June 16th, 2008


Transcript

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HIV 1

Hoofdstukken in deze video

0:07

Title

0:59

What are limitations of today's antiretroviral therapies

1:41

Excision of proviral DNA. Targeting LTR specific sequences.

3:39

Addressing the problem of multiple HIV isolates.

4:35

Generation of site-specific Tre recombinase via directed molecular evolution.

5:49

Delivery of Tre recombinase, HIV-1 proviral DNA excision, and elimination of HIV-1 viruses.

6:39

Open questions.

8:21

Towards a clinical application.

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